Agate Resources is a privately held company, developing innovative systems for healthcare management, education, products, services and research in ways beneficial for recipients of healthcare, contracting partners, and healthcare providers.

Apropo provides durable medical equipment benefits management to reduce costs, ensure quality, and expedite prior authorization and claims management. Apropo applies its expertise to provide solutions that meet widely varying expectations and brings an ethics-driven dedication and equitable regard to every stakeholder.

Center on Teaching and Learning (CTL) is a community of scholars whose mission is to conduct, translate, and disseminate research that focuses on the solutions and resolutions to serious but practical problems in school systems, including classrooms, schools, special education settings, and school districts. CTL seeks to advance the understanding and use of the most rigorous scientific evidence and research-based practices to prevent and intercept the academic difficulties that many school-aged children experience, particularly in subjects such a beginning reading, reading comprehension, spelling, mathematics, and selected content areas (e.g., social studies). The primary focus of this research group is the role of curriculum, instruction, and assessment as individual elements that interact in school systems. CTL’s research and outreach includes school-based experimental research, model demonstration projects, and large-scale professional development and technical assistance.

• Center to Improve Reading Competence Using Intensive Treatments Schoolwide (CIRCUITS) The overarching goal of CIRCUITS is to implement, evaluate, replicate, and disseminate systemic prevention models that will accelerate and sustain the early reading achievement of students with reading disabilities or at risk of disabilities in grades K-3.
  
  
• Oregon Reading First Center (ORFC) This center provides technical assistance to 51 schools in 21 school districts in the State of Oregon that participate in the Reading First Program, which was established as part of the No Child Left Behind. The goal of Reading First is to improve student achievement in reading through the application of scientifically based reading research, particularly for students who are struggling with reading.
  
  
• DIBELS Data System (DIBELS) This data systems provides web-based support for the Dynamic Indicators of Basic Early Literacy Skills (DIBELS) that are a set of standardized, individually administered measures of early literacy development. These measures are designed to be short one-minute fluency measures used to regularly monitor the development of pre-reading and early reading skills.
  

Computational Intelligence Research Laboratory (CIRL) is a UO research institute composed of top scientists conducting research in the field of artificial intelligence. The group researches new techniques in artificial intelligence to enhance the ability to plan a vast array of complex procedures, by creating algorithms that allow a computer to compile both a flexible pattern of problems solving, yet also consider all potential solutions. CIRL scientists optimize task order through improving scheduling and resource allocation, substantially improving an organization's productivity and competitiveness. A variety of other optimization problems, such as aircraft routing a minimize fuel use, are also being studied. CIRL research is licensed to On-Time Systems, Inc., a Eugene company that develops optimization applications.

Dune Sciences, LLC is an early-stage technology company that is striving to revolutionize the development of new materials through atomic and molecular scale engineering. Dune's initial product line of Smart GridsTM is a new multi-dimensional characterization platform that allows one to develop the most comprehensive understanding to date of the inner workings of the nanoscale world. In addition, Dune is focused on the development and commercialization of application-specific solutions involving the integration and assembly of molecular building blocks into functional value-added systems in the fields of medicine and energy.

Electrical Geodesics (EGI) is a direct spin-off from research in the UO's Psychology Department Brain Electrophysiology Laboratory and began in the Riverfront Innovation Center. EGI’s research and development teams work on core technologies for assessing brain function to applications of dense–array EEG technology to clinical problems. The success of the patented Geodesic Sensor Net, EEG electrode application is fast, painless and promotes faster exams and greater clinic productivity. EGI’s products allow for accurate measurement of brain activity, which is beneficial in treating strokes, presurgery planning, neonatal monitoring, epilepsy and dementia treatment, and other neurological monitoring. It designs, produces, and sells electrophysical neuroimaging equipment and related software, and employs undergraduates, graduate students, and postdoctoral fellows, serving as a training ground in the field of cognitive neuroscience.

Employers Health Alliance is a third party administrator that works with self-funded employers to provide claims administration and medical management services. They design cost-effective benefit plans tailored to the unique needs of each workforce and each company's benefit program goals.

Floragenex is an early stage biotechnology company. Using an innovative genetic mapping tool developed at the University of Oregon by co-founder Dr. Eric Johnson, Floragenex offers a better genetic map to customers seeking to understand the genetics behind unique physical traits in any organism. Floragenex target markets are plant breeders and basic research programs that need to more effectively map genetics of their chosen organism.

Office for the Protection of Human Subjects assumes the responsibility to ensure that federal, state and local guidelines are met for the protection of the rights and welfare of human subjects who participate in research and other activity projects conducted by faculty, staff, and students at the UO. The university maintains two institutional review board competent to review research involving human subjects and to evaluate both risk and protection against risks for those subjects.

Kaibridge, Inc. Kaibridge improves how people create and engage with animation across all platforms. Kaibridge is a spin-out of the University of Oregon Computer and Information Science Department.

Lane Home Medical (LHM) provides medical equipment and supplies to individuals and care facilities directly, or in the service of health plans to their memberships. They specialize in helping seniors and the disabled enjoy greater mobility and safety, thereby leading to more independent lives.

Lane Individual Practice Association (LIPA) is an inclusive physician organization that strives to foster through physician leadership, a cooperative environment in which participating physicians can provide and improve community access to high quality cost effective medical care for Oregon Health Plan patients.

Marker Gene Technologies (MGT), another company which started in the Research Park, was founded by an adjunct faculty member in the UO's Department of Chemistry. The company explores, develops, manufactures, and supplies biopharmaceuticals, reagents and molecular biology products for use in medical research and industrial biotechnology.  MGT collaborates with a number of biotechnology and pharmaceutical companies on successful, proprietary, and patented projects.  They also conduct business with the UO Monoclonal Antibody Facility and the Oregon Veterinary Services and Animal Care Facility at the UO.

MitoSciences, a spin-off from the UO's Monoclonal Antibody Facility specializing in mitochondrial structure and function, has licensed through the UO over 50 unique monoclonal antibodies against mitochondrial proteins. As an active research participant in the areas of genetic mitochondrial diseases, mitochondrial dysfunction from neurodegenerative diseases, mitochondria involvement in cancer and apoptosis, environmental toxins, oxidative stress, and side effects of therapeutic drugs, MitoSciences provides the best monoclonal antibodies in the world while providing experienced researchers that understand the nature of this research and can help maximize research efforts.

Office for the Protection of Human Subjects assumes the responsibility to ensure that federal, state and local guidelines are met for the protection of the rights and welfare of human subjects who participate in research and other activity projects conducted by faculty, staff, and students at the UO. The university maintains two institutional review board competent to review research involving human subjects and to evaluate both risk and protection against risks for those subjects.

On-Time Systems (OTS) is a local company established to transfer optimization technology developed at the university's Computational Intelligence Research Laboratory (CIRL) and elsewhere to practical applications for optimizing routing, scheduling, and industrial tasks for both government and industry. OTS' aircraft routing system WARP computes fuel-efficient routings while considering weather, aircraft weight and destination and other factors. The US Air Force uses WARP to route virtually all of their non-combat missions and saves one to three percent in fuel costs per year (approximately 15 million gallons of jet fuel annually). OTS has also developed scheduling software that reduces the cost of shipbuilding, potentially saving the Navy $500M annually.

Oregon Research Institute (ORI) is internationally known as a leader in the conduct of socially relevant research. ORI's work makes significant contributions to understanding the causes, prevention, and treatment of social and medical problems including adolescent depression, childhood behavioral problems, tobacco and other substance use, and chronic physical illness. Research projects housed in the Riverfront Research Park include studies on adolescent depression, adolescent physical activity and prevention and treatment of chronic illnesses. Some ORI administrative offices are located in the Riverfront Research Park.

Pacific Institutes for Research (PIR) conducts basic and applied educational research, particularly in the areas of early literacy, early numeracy, and effective instruction. The research staff is dedicated to improved academic and social outcomes for all students based on empirically proven methods. PIR is funded primarily through federal research grants through the U.S. Department of Education, and contracts with various agencies.

Technical Assistance and Consulting Services/Western Regional Resource Center (TACS/WRRC) provides technical assistance to state education and federal agencies to assist and support them in systemic improvement policies, procedures and practices which will result in quality programs and services for children with disabilities and their families. It offers consultations, technical assistance, training, product development and information services, including research.

Technology Transfer helps university inventions successfully make the transition from academia to the commercial marketplace. The office identifies promising early-stage research with strong commercial potential, brings in investors and support from corporate partners, and moves aggressively to license inventions to an existing company or to a spin-off company for further product development.

Zebrafish Information Network (ZFIN) is a web-based, worldwide resource that serves as a centralized location for the curation and integration of zebrafish genetic, genomic and developmental data. The zebrafish has emerged as a model organism important for the identification and characterization of genes and pathways involved in development, organ function, behavior and disease. ZFIN provides an integrated representation of mutants, genes, genetic markers, mapping panels, publications, and community contact data.